Posts Tagged ‘x57l’
Mirror neuron – Wikipedia
May 8, 2017Spindle neuron – Wikipedia
May 8, 2017https://en.wikipedia.org/wiki/Spindle_neuron
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Spindle neurons, also called von Economo neurons (VENs), are a specific class of neurons that are characterized by a large
spindle-shaped soma (or body), gradually tapering into a single apical axon in one direction, with only a single dendrite facing opposite. Other neurons tend to have many dendrites, and the polar-shaped morphology of spindle neurons is unique. A neuron’s dendrites receive signals, and its axon sends them.
Spindle neurons are found in two very restricted regions in the brains of hominids—the family of species comprising humans and other great apes—the anterior cingulate cortex (ACC) and the fronto-insular cortex (FI). Recently they have been discovered in the dorsolateral prefrontal cortex of humans.[1] Spindle cells are also found in the brains of the humpback whales, fin whales, killer whales, sperm whales,[2][3] bottlenose dolphin, Risso’s dolphin, beluga whales,[4] African and Asian elephants,[5] and to a lesser extent in macaque monkeys[6] and raccoons.[7] The appearance of spindle neurons in distantly related clades suggests that they represent convergent evolution, specifically an adaptation to larger brains.
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Patterns and functional implications of rare germline variants across 12 cancer types : Nature Communications : Nature Publishing Group
May 8, 2017Patterns…of rare germline variants across 12 cancers http://www.Nature.com/ncomms/2015/151209/ncomms10086/full/ncomms10086.html TCGA v NHLBI exomes finds enriched LOFs + some gene burdening[category scilit]
molecular stickers
April 30, 2017Updated list of molecular stickers available from Amazon
Xanax Alprazolam Molecule Molecular Model
https://www.amazon.com/Xanax-Alprazolam-Molecule-Molecular-Model/dp/B00LMJMID0/
Cocaine Chemical Structure – Laptop Decal – Black 5″
https://www.amazon.com/Cocaine-Chemical-Structure-Laptop-Decal/dp/B00AUIXOMI Benzoylmethylecgonine
LSD Chemical Structure – Laptop Decal – Black 5″
https://www.amazon.com/LSD-Chemical-Structure-Laptop-Decal/dp/B00AUIS8GA
Morphine Chemical Structure – Laptop Decal – Black 5″
https://www.amazon.com/Morphine-Chemical-Structure-Laptop-Decal/dp/B00AUITAK8
Heroine Chemical Structure – Laptop Decal – Black 5″
https://www.amazon.com/Heroine-Chemical-Structure-Laptop-Decal/dp/B00AUIRTG0
Marijuana Chemical Structure – Laptop Decal – Black 5″
https://www.amazon.com/Marijuana-Chemical-Structure-Laptop-Decal/dp/B00AUISLKS THC Tetrahydrocannabinol Marijuana Molecule Molecular Model – 6″ Black
Ecstasy Chemical Structure – Laptop Decal – Black 5”
https://www.amazon.com/Ecstasy-Chemical-Structure-Laptop-Decal/dp/B00AU5SM7I MDMA
Adrenaline Epinepherine Molecule Molecular Model – 6″ Black Vinyl
Amphetamine Salts Adderall ADHD Molecule Molecular
Model – 6″ Black Vinyl Decal Sticker
Caffeine Molecule Molecular Model – 5″ Black Vinyl Decal Sticker
Serotonin 5-Hydroxytryptamine Molecule – 6″ Black Vinyl Decal Sticker
Yet more:
EtOH (Alcohol)
https://www.amazon.com/Ethanol-Molecule-Alcohol-Molecular-Model/dp/B00ICQ9F1O
“Alcohol-like” sticker – what is this ?
https://www.amazon.com/Molecule-Decal-Chemical-Compound-Structure/dp/B018A10QLI
molecular stickers
April 4, 2017List of molecular stickers available from Amazon
Cocaine Chemical Structure – Laptop Decal – Black 5″
https://www.amazon.com/Cocaine-Chemical-Structure-Laptop-Decal/dp/B00AUIXOMI Benzoylmethylecgonine
LSD Chemical Structure – Laptop Decal – Black 5″
https://www.amazon.com/LSD-Chemical-Structure-Laptop-Decal/dp/B00AUIS8GA
Morphine Chemical Structure – Laptop Decal – Black 5″
https://www.amazon.com/Morphine-Chemical-Structure-Laptop-Decal/dp/B00AUITAK8
Heroine Chemical Structure – Laptop Decal – Black 5″
https://www.amazon.com/Heroine-Chemical-Structure-Laptop-Decal/dp/B00AUIRTG0
Marijuana Chemical Structure – Laptop Decal – Black 5″
https://www.amazon.com/Marijuana-Chemical-Structure-Laptop-Decal/dp/B00AUISLKS THC Tetrahydrocannabinol Marijuana Molecule Molecular Model – 6″ Black
Ecstasy Chemical Structure – Laptop Decal – Black 5”
https://www.amazon.com/Ecstasy-Chemical-Structure-Laptop-Decal/dp/B00AU5SM7I MDMA
Adrenaline Epinepherine Molecule Molecular Model – 6″ Black Vinyl
Amphetamine Salts Adderall ADHD Molecule Molecular
Model – 6″ Black Vinyl Decal Sticker
Caffeine Molecule Molecular Model – 5″ Black Vinyl Decal Sticker
Serotonin 5-Hydroxytryptamine Molecule – 6″ Black Vinyl Decal Sticker
Yet more:
EtOH (Alcohol)
https://www.amazon.com/Ethanol-Molecule-Alcohol-Molecular-Model/dp/B00ICQ9F1O
“Alcohol-like” sticker – what is this ?
https://www.amazon.com/Molecule-Decal-Chemical-Compound-Structure/dp/B018A10QLI
How To Host a Simple Website Using Dropbox
April 4, 2017NAR Breakthrough Article: denovo-db: a compendium of human de novo variants
April 3, 2017.@denovodb: a compendium of [initially ~33K] human de novo variants w. phenotype, freely downloadable as a TSV table
https://academic.OUP.com/nar/article-lookup/doi/10.1093/nar/gkw865
QT:{{”
As of July 2016, denovo-db contained 40 different studies and 32,991 de novo variants from 23,098 trios. Database features include basic variant information (chromosome location, change, type); detailed annotation at the transcript and protein levels; severity scores; frequency; validation status; and, most importantly, the phenotype of the individual with the variant.
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denovo-db.gs.washington.edu/denovo-db/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210614/
interesting paper
February 22, 2017Partitioning heritability of regulatory…variants across 11 common diseases http://www.Cell.com/ajhg/abstract/S0002-9297(14)00426-1 Almost 80% #noncoding v 10% coding
The paper below claims to find most of the heritability of 11 common diseases in regulatory regions (79% of heritability found in regulatory regions, <10% in protein coding regions).
Partitioning heritability of regulatory and cell-type-specific variants across 11 common
diseases.
Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, Stahl E; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M, Pasaniuc B, Sullivan PF, Neale BM, Wray NR, Raychaudhuri S, Price AL; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium.
Am J Hum Genet. 2014 Nov 6;95(5):535-52. doi:
10.1016/j.ajhg.2014.10.004. Epub 2014 Nov 6.
Best Practices for Scientific Computing
February 5, 2017also from ’14:
https://plus.google.com/+MarkGerstein/posts/D8kYoqiWL1P
Best Practices for Sci Computing
http://journals.PLOS.org/plosbiology/article?id=10.1371/journal.pbio.1001745 Usual stuff (GitHub, profilers, assertions) + some gems (turn bugs into test cases)
