Posts Tagged ‘x57l’
How To Host a Simple Website Using Dropbox
April 4, 2017NAR Breakthrough Article: denovo-db: a compendium of human de novo variants
April 3, 2017.@denovodb: a compendium of [initially ~33K] human de novo variants w. phenotype, freely downloadable as a TSV table
https://academic.OUP.com/nar/article-lookup/doi/10.1093/nar/gkw865
QT:{{”
As of July 2016, denovo-db contained 40 different studies and 32,991 de novo variants from 23,098 trios. Database features include basic variant information (chromosome location, change, type); detailed annotation at the transcript and protein levels; severity scores; frequency; validation status; and, most importantly, the phenotype of the individual with the variant.
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denovo-db.gs.washington.edu/denovo-db/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210614/
interesting paper
February 22, 2017Partitioning heritability of regulatory…variants across 11 common diseases http://www.Cell.com/ajhg/abstract/S0002-9297(14)00426-1 Almost 80% #noncoding v 10% coding
The paper below claims to find most of the heritability of 11 common diseases in regulatory regions (79% of heritability found in regulatory regions, <10% in protein coding regions).
Partitioning heritability of regulatory and cell-type-specific variants across 11 common
diseases.
Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, Stahl E; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M, Pasaniuc B, Sullivan PF, Neale BM, Wray NR, Raychaudhuri S, Price AL; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium.
Am J Hum Genet. 2014 Nov 6;95(5):535-52. doi:
10.1016/j.ajhg.2014.10.004. Epub 2014 Nov 6.
Best Practices for Scientific Computing
February 5, 2017also from ’14:
https://plus.google.com/+MarkGerstein/posts/D8kYoqiWL1P
Best Practices for Sci Computing
http://journals.PLOS.org/plosbiology/article?id=10.1371/journal.pbio.1001745 Usual stuff (GitHub, profilers, assertions) + some gems (turn bugs into test cases)
Best Practices for Scientific Computing
January 22, 2017Best Practices for Sci Computing
http://journals.PLOS.org/plosbiology/article?id=10.1371/journal.pbio.1001745 Usual stuff (GitHub, profilers, assertions) + some gems (turn bugs into test cases)
Samsung Galaxy S7 | Verizon Wireless
December 18, 2016can use w/ microSD
QT:{{”
Expand the phone’s 32GB memory+++ up to eight times with a 256GB microSD card. “}}
https://www.verizonwireless.com/smartphones/samsung-galaxy-s7/
The Pangenome: Are Single Reference Genomes Dead? | The Scientist Magazine(R)
December 17, 2016The #Pangenome: Are Single Reference Genomes Dead? YES!
http://www.The-Scientist.com/?articles.view/articleNo/47510/title/The-Pangenome–Are-Single-Reference-Genomes-Dead-/ Division into conserved/core & dispensable/variable genes
Why Elephants Don’t Get Cancer—and What That Means for Humans
December 17, 2016Why Elephants Don’t Get Cancer – many TP53 copies
http://www.newsweek.com/2015/10/16/researchers-studying-elephants-improve-cancer-treatment-380822.html Result of #Peto’s Paradox: More cells don’t lead to more disease
see dog species
BrainSpan genotypes
December 9, 2016There are BrainSpan genotypes available through dbGAP:
https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000406.v1.p1
linkstream2 microblog 