https://www.cell.com/cell/fulltext/S0092-8674(21)01279-4
A single-cell atlas of chromatin accessibility in the human genome
Kai Zhang 8
James D. Hocker 8
Michael Miller
….
Allen Wang
Sebastian Preissl
Bing Ren 9
Published:November 12, 2021
DOI:https://doi.org/10.1016/j.cell.2021.10.024
Liked this @KharchenkoLab review – in particular, the descriptions of the various low-dimensional approximations & the simple motivation for these using PCA. Also, found the step-by-step workflow in the text & figures helpful.
Note also the reference to expression entropy for determining the direction in trajectories.
Review Article
Published: 21 June 2021
The triumphs and limitations of computational methods for scRNA-seq
Peter V. Kharchenko
Nature Methods volume 18, pages723–732 (2021)
UK Biobank Study Investigates Incomplete Penetrance of Mendelian Disease Variants
Oct 21, 2021 | Julia Karow
Remove from my reading list
NEW YORK – Recessive Mendelian disorders are caused by mutations in both copies of a gene, but heterozygous carriers can sometimes also show mild phenotypes.
To study such incomplete penetrance of disease variants in greater detail, researchers have analyzed genetic data from the UK Biobank.
…
https://www.fastcompany.com/90685280/notion-coda-microsoft-word-alternatives interesting checklist features, perhaps moving into gdocs
https://www.cell.com/ajhg/fulltext/S0002-9297(16)30526-2
Expanding Access to Large-Scale Genomic Data While Promoting Privacy: A Game Theoretic Approach
Zhiyu Wan
Yevgeniy Vorobeychik
Weiyi Xia
Ellen Wright Clayton
Murat Kantarcioglu
Bradley Malin
Published:January 05, 2017
DOI:https://doi.org/10.1016/j.ajhg.2016.12.002
