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QT:{{”
In a recent issue of Cell Metabolism, Guarente co-authored a review article about human trials exploring compounds that target pathways and mechanisms of aging along with David Sinclair, Ph.D., one of Dr. Guarente’s postdoctoral mentees and now a professor of genetics at Harvard Medical School, and Guido Kroemer, M.D., Ph.D., a professor at the Université Paris Cité. Guarente and his colleagues focus on eight drugs and compounds: metformin, NAD+ precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatories.
These interventions made the list for four reasons: 1) they’re well-represented in ongoing or completed human clinical trials; 2) they’ve been shown to slow aging in preclinical studies; 3) they’re thought to be sufficiently safe for long-term use in humans; and 4) they work by targeting the hallmarks of aging.
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https://onlinelibrary.wiley.com/doi/10.1111/php.13866
Görlitz, M., Justen, L., Rochette, P. J., Buonanno, M., Welch, D., Kleiman, N. J., Eadie, E., Kaidzu, S., Bradshaw, W. J., Javorsky, E., Cridland, N., Galor, A., Guttmann, M., Meinke, M. C., Schleusener, J., Jensen, P., Söderberg, P., Yamano, N., Nishigori, C., . . . Esvelt, K. (2023). Assessing the safety of new germicidal far‐UVC technologies. Photochemistry and Photobiology, 100(3), 501–520.
https://doi.org/10.1111/php.13866
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