Post-transcriptional reg…across…tissues [v genes], by @SlavovLab http://journals.PLoS.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005535 Simpson’s paradox! Diff in protein-mRNA corr.
Archive for the 'SciLit' Category
Post-transcriptional regulation across human tissues
July 16, 2017Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. – PubMed – NCBI
July 10, 2017https://www.ncbi.nlm.nih.gov/pubmed/24267887
Cell. 2013 Nov 21;155(5):1008-21. doi: 10.1016/j.cell.2013.10.031.
Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism.
Parikshak NN1, Luo R, Zhang A, Won H, Lowe JK, Chandran V, Horvath S, Geschwind DH.
Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. – PubMed – NCBI
July 10, 2017https://www.ncbi.nlm.nih.gov/pubmed/24267886
Cell. 2013 Nov 21;155(5):997-1007. doi: 10.1016/j.cell.2013.10.020.
Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism.
Willsey AJ1, Sanders SJ, Li M, Dong S, Tebbenkamp AT, Muhle RA, Reilly SK, Lin L, Fertuzinhos S, Miller JA, Murtha MT, Bichsel C, Niu W, Cotney J, Ercan-Sencicek AG, Gockley J, Gupta AR, Han W, He X, Hoffman EJ, Klei L, Lei J, Liu W, Liu L, Lu C, Xu X, Zhu Y, Mane SM, Lein ES, Wei L, Noonan JP, Roeder K, Devlin B, Sestan N, State MW.
Using brainspan to see where ASD genes are enriched in certain developmental times
Integrated Model of De Novo and Inherited Genetic Variants Yields Greater Power to Identify Risk Genes
July 10, 2017http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003671
TADA tool, integrates evidence
Integrated Model of De Novo and Inherited Genetic Variants Yields Greater Power to Identify Risk Genes
Xin He,
Stephan J. Sanders,
Li Liu,
Silvia De Rubeis,
Elaine T. Lim,
James S. Sutcliffe,
Gerard D. Schellenberg,
Richard A. Gibbs,
Mark J. Daly,
Joseph D. Buxbaum,
Matthew W. State,
Bernie Devlin,
Kathryn Roeder
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways : Nature Neuroscience : Nature Research
July 10, 2017https://www.nature.com/neuro/journal/v18/n2/full/nn.3922.html
older stats approach
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways : Nature Neuroscience : Nature Research
A comprehensive review of genetic association studies. – PubMed – NCBI
July 10, 2017https://www.ncbi.nlm.nih.gov/pubmed/11882781
QT:{{"
We find that over 600 positive associations between common gene variants and disease have been reported; these associations, if correct, would have tremendous importance for the prevention, prediction, and treatment of most common diseases. However, most reported associations are not robust: of the 166 putative associations which have been studied three or more times, only 6 have been consistently replicated.
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Genetic architectures of psychiatric disorders: the emerging picture and its implications. – PubMed – NCBI
July 10, 2017https://www.ncbi.nlm.nih.gov/pubmed/22777127
has a nice plot showing heritability of these conditions
linkstream2 microblog 