good dev fig?
Archive for the 'SciLit' Category
Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. – PubMed – NCBI
July 10, 2017https://www.ncbi.nlm.nih.gov/pubmed/24267887
Cell. 2013 Nov 21;155(5):1008-21. doi: 10.1016/j.cell.2013.10.031.
Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism.
Parikshak NN1, Luo R, Zhang A, Won H, Lowe JK, Chandran V, Horvath S, Geschwind DH.
Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. – PubMed – NCBI
July 10, 2017https://www.ncbi.nlm.nih.gov/pubmed/24267886
Cell. 2013 Nov 21;155(5):997-1007. doi: 10.1016/j.cell.2013.10.020.
Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism.
Willsey AJ1, Sanders SJ, Li M, Dong S, Tebbenkamp AT, Muhle RA, Reilly SK, Lin L, Fertuzinhos S, Miller JA, Murtha MT, Bichsel C, Niu W, Cotney J, Ercan-Sencicek AG, Gockley J, Gupta AR, Han W, He X, Hoffman EJ, Klei L, Lei J, Liu W, Liu L, Lu C, Xu X, Zhu Y, Mane SM, Lein ES, Wei L, Noonan JP, Roeder K, Devlin B, Sestan N, State MW.
Using brainspan to see where ASD genes are enriched in certain developmental times
Integrated Model of De Novo and Inherited Genetic Variants Yields Greater Power to Identify Risk Genes
July 10, 2017http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003671
TADA tool, integrates evidence
Integrated Model of De Novo and Inherited Genetic Variants Yields Greater Power to Identify Risk Genes
Xin He,
Stephan J. Sanders,
Li Liu,
Silvia De Rubeis,
Elaine T. Lim,
James S. Sutcliffe,
Gerard D. Schellenberg,
Richard A. Gibbs,
Mark J. Daly,
Joseph D. Buxbaum,
Matthew W. State,
Bernie Devlin,
Kathryn Roeder
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways : Nature Neuroscience : Nature Research
July 10, 2017https://www.nature.com/neuro/journal/v18/n2/full/nn.3922.html
older stats approach
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways : Nature Neuroscience : Nature Research
A comprehensive review of genetic association studies. – PubMed – NCBI
July 10, 2017https://www.ncbi.nlm.nih.gov/pubmed/11882781
QT:{{"
We find that over 600 positive associations between common gene variants and disease have been reported; these associations, if correct, would have tremendous importance for the prevention, prediction, and treatment of most common diseases. However, most reported associations are not robust: of the 166 putative associations which have been studied three or more times, only 6 have been consistently replicated.
"}}
Genetic architectures of psychiatric disorders: the emerging picture and its implications. – PubMed – NCBI
July 10, 2017https://www.ncbi.nlm.nih.gov/pubmed/22777127
has a nice plot showing heritability of these conditions
promoter/enhancer categorization and Encyclopedia
July 1, 2017Genome-wide characterization of..promoters w…enhancer functions http://www.Nature.com/ng/journal/v49/n7/full/ng.3884.html Blurs distinction betw these, suggests flexibility
Genome-wide characterization of mammalian promoters with distal enhancer functions
Lan T M Dao,
Ariel O Galindo-Albarrán,
Jaime A Castro-Mondragon,
Charlotte Andrieu-Soler,
Alejandra Medina-Rivera,
Charbel Souaid,
Guillaume Charbonnier,
Aurélien Griffon,
Laurent Vanhille,
Tharshana Stephen,
Jaafar Alomairi,
David Martin,
Magali Torres,
Nicolas Fernandez,
Eric Soler,
Jacques van Helden,
Denis Puthier
& Salvatore Spicuglia
Promoting transcription over long distances
Rui R Catarino,
Christoph Neumayr
& Alexander Stark
Nature Genetics 49, 972–973 (2017) doi:10.1038/ng.3904
28 June 2017
http://www.nature.com/ng/journal/v49/n7/full/ng.3884.html
http://www.nature.com/ng/journal/v49/n7/full/ng.3904.html
QT:{{”
“Should we be surprised that promoters can function as enhancers—or better—that enhancers and promoter regions can overlap? Probably not: the habit of annotating different genomic regions with distinct labels ignores the fact that DNA sequences typically encode different genetic functions in a rather flexible manner. Enhancers and promoters are determined by the presence of short degenerate motifs, and even protein-coding regions display flexibility due to the degeneracy of the genetic code. Therefore, a single DNA sequence can encode different types of functions, including enhancer function of protein-coding regions or—as shown now—enhancer function of
promoters.”
“}}
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