Massively parallel quantification of…regulatory effects of #noncoding…variation in a…cohort
http://genome.cshlp.org/content/25/8/1206.long new popstarr assay
http://www.ncbi.nlm.nih.gov/pubmed/26084464
Genome Res. 2015 Aug;25(8):1206-14. doi: 10.1101/gr.190090.115. Epub 2015 Jun 17.
Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort.
Vockley CM1, Guo C2, Majoros WH3, Nodzenski M4, Scholtens DM4, Hayes MG5, Lowe WL Jr5, Reddy TE6.
Life history of retrocopies [incl. ~5k #pseudogenes]
illuminates…evolution
http://genome.cshlp.org/content/early/2016/01/04/gr.198473.115 Suggests modes of promotor acquisition
[tag
from,fn,from_fn,jclub,pseudogenes,u41pg,evolution,gencode,cmppgene]
Reprogramming…#epigenome & transcriptome in…muscle after training http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622000/ Delta(Me) from #exercise in 1 leg v. other
QT:{{”
Exercise has long been known to have an effect on health, lowering the incidence of cardiovascular disease, obesity, and type 2 diabetes. Recently, it has been found that exercise can have a direct effect on DNA methylation and gene expression. A group of 23 subjects exercised one leg but not the other for 45 minutes four times a week for three months. At the end of this period, the methylation and gene expression patterns were different in the exercised leg relative to the one that did not exercise, indicating a direct effect of exercise on
epigenetics.
“}}
Quote from:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987618/
Aging Pathways: insulin-foxo, mTOR, AMPK, Sirtuin
A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
Zhenglin Yang1,2,3,*,
Nicola J. Camp4,*,
Hui Sun5,
Zongzhong Tong1,2,
Daniel Gibbs1,2,
D. Joshua Cameron1,2,
Haoyu Chen1,2,
Yu Zhao1,2,
Erik Pearson1,2,
Xi Li1,2,
Jeremy Chien6,
Andrew DeWan7,
Jennifer Harmon1,2,
Paul S. Bernstein1,
Viji Shridhar6,
Norman A. Zabriskie1,
Josephine Hoh7,
Kimberly Howes1,
Kang Zhang1,2,†
http://science.sciencemag.org/content/314/5801/992
QT:{{”
Age-related macular degeneration results in blindness, and one major locus (HTRAX) accounts for approximately one-half of genetic cases. “}}
Should be HTRA1
http://ghr.nlm.nih.gov/condition/age-related-macular-degeneration
Similarity #network fusion for aggregating data types
http://www.nature.com/nmeth/journal/v11/n3/full/nmeth.2810.html Combines mRNA, miRNA & gene fusions to classify cancer subtypes http://compbio.cs.toronto.edu/SNF/SNF
.@emblEBI in ’16 via @ewanbirney
http://europepmc.org/articles/PMC4702932/ Seq DB growth stable w/ yearly doubling (post ~’08 spike) & EGA now faster than ENA
cite the data growth stats here:
http://europepmc.org/articles/PMC4702932/figure/F2/
Fig 2
– amt prvt data incr as for ncbi + arrays are falling now less than masspec – after a huge incr from ’07 to ’12 , now stab. at12-mo doubling
linkstream2 microblog 