Archive for the 'SciLit' Category

Dissecting Disease Inheritance Modes in a Three-Dimensional Protein Network Challenges the “Guilt-by-Asso ciation” Principle

July 19, 2014

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710751/

surprisingly, no positional effects on LOF mutations … significant proportion of truncation alleles give rise to functional products

“guilt by assoc works”

signif. number dom mut give rise to func products

enhancer functional test

July 19, 2014

High-throughput functional testing of ENCODE segmentation predictions

http://genome.cshlp.org/content/early/2014/07/17/gr.173518.114.abstract?papetoc

Mirsynergy: detecting synergistic miRNA regul… Bioinformatics. 2014 – PubMed – NCBI

July 19, 2014

Mirsynergy: detecting synergistic #miRNA regulatory modules by… neighborhood expansion
http://www.ncbi.nlm.nih.gov/pubmed/24894504 creates overlapping clusters

Ensemble Methods in Machine Learning. Proceedings of the First International Workshop on Multiple Classifier Systems

July 13, 2014

Rich C, Alexandru N-M, Geoff C, Alex K (2004) Ensemble selection from libraries of
models. Proceedings of the twenty-first international conference on Machine learning. Banff, Alberta, Canada: ACM.
http://www.niculescu-mizil.org/papers/shotgun.icml04.revised.rev2.pdf

Thomas GD (2000) Ensemble Methods in Machine Learning. Proceedings of the First International Workshop on Multiple Classifier Systems: Springer-Verlag.
http://www.eecs.wsu.edu/~holder/courses/CptS570/fall07/papers/Dietterich00.pdf http://dl.acm.org/citation.cfm?id=743935

.@deniseOme Good ref is TG Dietterich #Ensemble Methods in
#MachineLearning MCS ’00
http://www.eecs.wsu.edu/~holder/courses/CptS570/fall07/papers/Dietterich00.pdf Not rel. to @ensembl #ismb #afp14

ref 17 & 18

BMC Bioinformatics | Full text | A new measure for functional similarity of gene products based on Gene Ontology

July 12, 2014

BMC Bioinformatics | Full text | A new measure for functional similarity of gene products based on Gene Ontology
http://www.biomedcentral.com/1471-2105/7/302

Related to:
http://papers.gersteinlab.org/papers/funcsim/

Information-theoretic evaluation of predicted ontological annotations

July 12, 2014

http://bioinformatics.oxfordjournals.org/content/29/13/i53.short

Predicting phenotype from patterns of annotation

July 12, 2014

Roth lab paper
http://bioinformatics.oxfordjournals.org/content/19/suppl_1/i183.long

Manual curation is not sufficient for annotation of genomic databases

July 12, 2014

Hunter lab pub

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516305/

PLOS ONE: The Impact of Multifunctional Genes on “Guilt by Association” Analysis

July 12, 2014

Pavlidis mentions: …Multifunctional Genes…
http://www.plosone.org/article/info%253Adoi%252F10.1371%252Fjournal.pone.0017258 … hubbiness predicts these better than more complex methods #ismb #afp14

Network Biology Publications

July 12, 2014

http://netbiopub.tumblr.com
associated w/ linkedin group