Archive for the 'SciLit' Category
Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude
May 8, 2014Contains a tree-based way of determining positive selection
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism
April 27, 2014Protein… #network of alternatively spliced isoforms from brain…: Half of the interactions from #splicing variants
http://www.nature.com/ncomms/2014/140411/ncomms4650/abs/ncomms4650.html
PLOS ONE: Burst of Young Retrogenes and Independent Retrogene Formation in Mammals
April 19, 2014Burst of Young Retrogenes…in Mammals. Discusses much
retro-transposition ~40 Mya, relevant to proc. #pseudogenes
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005040
Also, ref #11 provides more detail on this.
Encode-annotation interesting paper
April 14, 2014recent publication from the Donnelly group comparing using GENCODE or Refeq annotation when predicting variants effects.
Choice of transcripts and software has a large effect on variant annotation
Genome Medicine 2014, 6:26 doi:10.1186/gm543
Access : Surfing the p53 network : Nature
April 12, 2014Original article emphasizing the importance of networks to cancer
http://www.nature.com/nature/journal/v408/n6810/full/408307a0.html
A paper that was done by Vogelstein, Lane and Levine in Nature (2000, November 16) that talks about how cancer is associated with a network and these network of genes associated with p53. This is in response to the idea that p53 is such a crucial molecule in cancer as a tumor suppressor and it marks well known cancer biologists discussing this from a network perspective.
linkstream2 microblog 