Posts Tagged ‘cornerstone’
New large-scale QTL cohort
September 28, 2024Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution – ScienceDirect
November 25, 2022https://www.sciencedirect.com/science/article/pii/S0092867422012582
https://twitter.com/ry_lister/status/1587101557010489344
Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution
Author links open overlay panelCharles A.Herring1210Rebecca
K.Simmons1210SaskiaFreytag1210DanielPoppe1210Joel
J.D.Moffet1JahnviPflueger12SamBuckberry12Dulce
B.Vargas-Landin12OlivierClément12Enrique GoñiEcheverría1Gavin J.Sutton3AlbaAlvarez-Franco4RuiHou1ChristianPflueger12KerrieMcDonald5Jose M.Polo67Alistair R.R.Forrest1Anna K.Nowak8…RyanLister1211
serotonin & depression
August 28, 2022https://www.nature.com/articles/s41380-022-01661-0
QT:{{”
For decades, doctors believed ssris operated by boosting levels of serotonin, a chemical which carries signals between neurons in the brain. This supposition was based on the hypothesis that a lack of serotonin causes depression. But a growing number of investigations suggest that theory does not hold water—a conclusion hammered home by a round-up of reviews of such work just published in Molecular Psychiatry.
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SLC6A4 Gene – GeneCards | SC6A4 Protein | SC6A4 Antibody
August 1, 2022https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC6A4
QT:{{”
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]
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famous serotonin re-update transporter
Brain tissue expression of SST – Summary – The Human Protein Atlas
May 22, 2022https://www.proteinatlas.org/ENSG00000157005-SST/brain
gene & also cell type
Single cell type – PVALB – The Human Protein Atlas
May 22, 2022ScEQTL
May 12, 2022https://www.nature.com/articles/s41586-022-04713-1
Published: 11 May 2022
Single-cell eQTL models reveal dynamic T cell state dependence of disease loci Aparna Nathan, Samira Asgari, Kazuyoshi Ishigaki, Cristian Valencia, Tiffany Amariuta, Yang Luo, Jessica I. Beynor, Yuriy Baglaenko, Sara Suliman, Alkes L. Price, Leonid Lecca, Megan B. Murray, D. Branch Moody & Soumya Raychaudhuri
Nature (2022)
NRGN Gene – GeneCards | NEUG Protein | NEUG Antibody
May 9, 2022https://www.genecards.org/cgi-bin/carddisp.pl?gene=NRGN
Aging related gene in capstone4
linkstream2 microblog 