Recently discovered the Up-Goer Five website
(https://splasho.com/upgoer5) from the
@NaturePodcast. It makes you write text using only the thousand (or ‘ten hundred’) most common words. Great for removing jargon & forcing you to explain science in the simplest possible way.
Posts Tagged ‘from’
The Up-Goer Five Text Editor
January 24, 2022The power of genetic diversity in genome-wide association studies of lipids | Nature
January 10, 2022https://www.nature.com/articles/s41586-021-04064-3
some focus on its main method
MR-MEGA
https://academic.oup.com/hmg/article/26/18/3639/3976569
science
January 8, 2022Published: 05 January 2022
Decoding gene regulation in the fly brain
Jasper Janssens, Sara Aibar, Ibrahim Ihsan Taskiran, Joy N. Ismail, Alicia Estacio Gomez, Gabriel Aughey, Katina I. Spanier, Florian V. De Rop, Carmen Bravo González-Blas, Marc Dionne, Krista Grimes, Xiao Jiang Quan, Dafni Papasokrati, Gert Hulselmans, Samira Makhzami, Maxime De Waegeneer, Valerie Christiaens, Tony Southall & Stein Aerts Nature (2022)
Nature paper today on Fly brain GRNs, https://doi.org/10.1038/s41586-021-04262-z
Some integrative analyses might be useful…
These Prenatal Tests Are Usually Wrong When Warning of Rare Disorders – The New York Times
January 5, 2022https://www.nytimes.com/2022/01/01/upshot/pregnancy-birth-genetic-testing.html
A large number of FPs often results from applying even a good classifier on a very unbalanced data set (i.e. many more negatives than positives) – as is the case here. The situation is further exacerbated when the classifier is trained & benchmarked on a more balanced data set.
…
I think the situation here is similar to that found in cancer identification or finding a terrorist at airport security.
TrainingPeaks | Reclaim Your Race Day
January 4, 2022520 Grando | Trek Bikes
December 24, 2021COVID antiviral pills: what scientists still want to know
December 18, 2021QT:{{”
Molnupiravir acts by introducing mutations into the viral genome during viral replication. A metabolite of the drug is picked up by a viral enzyme called RNA-dependent RNA polymerase and incorporated into the viral genome, eventually causing so many errors that the virus can no longer survive.
…
Paxlovid acts by inhibiting an enzyme that’s needed to process some viral proteins into their final, functional form. But the drug is a combination of an antiviral and another drug, called ritonavir, which helps to prevent enzymes in the liver from breaking down the antiviral before it has a chance to disable the coronavirus. Ritonavir, a component of some HIV treatment cocktails, can affect how some other medications are metabolized by the body.
“}}
Molnupiravir & Paxlovid
https://www.nature.com/articles/d41586-021-03074-5
Why there is no such thing as a healthy diet that works for everyone | New Scientist
December 18, 2021An interesting paper with implications for personalized nutrition, suggested to me by
@DrGarrettAsh1
https://link.springer.com/article/10.1007%2Fs13300-021-01174-z Gut Microbiome Activity Contributes to Prediction of Individual Variation in Glycemic Response in Adults
…
Represents an update to “Personalized Nutrition by Prediction of Glycemic Responses” from the
@segal_eran
lab (https://cell.com/fulltext/S0092-8674(15)01481-6)
cell.com
Personalized Nutrition by Prediction of Glycemic Responses
…
Also, I felt this easy to read
@NewScientist
overview was quite relevant to these works & put them into a larger
context https://newscientist.com/article/mg24732990-600-why-there-is-no-such-thing-as-a-healthy-diet-that-works-for-everyone/ Why there is no such thing as a healthy diet that works for everyone
linkstream2 microblog 