https://www.nature.com/articles/s41531-025-01214-6
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Posts Tagged ‘jl’
Recent Parkinsons paper from Oxford
December 8, 2025
Rare genetic variants confer a high risk of ADHD and implicate neuronal biology | Nature
November 23, 2025https://www.nature.com/articles/s41586-025-09702-8
Demontis, D., Duan, J., Hsu, Y. H., Pintacuda, G., Grove, J., Nielsen, T. T., Thirstrup, J., Martorana, M., Botts, T., Satterstrom, F. K., Bybjerg-Grauholm, J., Tsai, J. H. Y., Glerup, S., Hoogman, M., Buitelaar, J., Klein, M., Ziegler, G. C., Jacob, C., Grimm, O., . . . Børglum, A. D. (2025). Rare genetic variants confer a high risk of ADHD and implicate neuronal biology. Nature.
https://doi.org/10.1038/s41586-025-09702-8
QT:{{”
Common genetic variants associated with the disorder have been identified12,13, but the role of rare variants in ADHD is mostly unknown. Here, by analysing rare coding variants in exome-sequencing data from 8,895 individuals with ADHD and 53,780 control individuals, we identify three genes (MAP1A, ANO8 and ANK2; P < 3.07 × 10−6; odds ratios 5.55–15.13) that are implicated in ADHD.
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serotonin & depression
August 28, 2022https://www.nature.com/articles/s41380-022-01661-0
QT:{{”
For decades, doctors believed ssris operated by boosting levels of serotonin, a chemical which carries signals between neurons in the brain. This supposition was based on the hypothesis that a lack of serotonin causes depression. But a growing number of investigations suggest that theory does not hold water—a conclusion hammered home by a round-up of reviews of such work just published in Molecular Psychiatry.
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SLC6A4 Gene – GeneCards | SC6A4 Protein | SC6A4 Antibody
August 1, 2022https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC6A4
QT:{{”
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]
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famous serotonin re-update transporter
foodlab
July 3, 2021Here’s Kenji’s YouTube channel (almost a million subscribers):
https://www.youtube.com/channel/UCqqJQ_cXSat0KIAVfIfKkVA
His videos are a similar style to his book, where he sometimes talks about science. For example in this video:
https://www.youtube.com/watch?v=U3gvRjIQ6Lo
At the 1:45 mark, he talks about the physics behind selecting tomatoes At the 4:01 mark, he talks about boiling water (volume, heat, etc) in relation to cooking pasta
2020 trends
December 30, 2020Photopea and Polarr- browser based editors
August 6, 2019The browser-based photoshop editor…is
(It’s more like a lite version of photoshop with all the functionality an amateur might ever use. Accepts photoshop, GIMP, etc. file formats in addition to other standard file formats.)
For a web-based Lightroom alternative – https://v2.polarr.co/#.
MS surface 2
May 18, 2018https://youtu.be/7DbslbKsQSk
note taking to a whole different level
linkstream2 microblog 
