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science
January 8, 2022Published: 05 January 2022
Decoding gene regulation in the fly brain
Jasper Janssens, Sara Aibar, Ibrahim Ihsan Taskiran, Joy N. Ismail, Alicia Estacio Gomez, Gabriel Aughey, Katina I. Spanier, Florian V. De Rop, Carmen Bravo González-Blas, Marc Dionne, Krista Grimes, Xiao Jiang Quan, Dafni Papasokrati, Gert Hulselmans, Samira Makhzami, Maxime De Waegeneer, Valerie Christiaens, Tony Southall & Stein Aerts Nature (2022)
Nature paper today on Fly brain GRNs, https://doi.org/10.1038/s41586-021-04262-z
Some integrative analyses might be useful…
A wider field of view to predict expression | Nature Methods
November 10, 2021A gene sequence-to-expression machine learning model achieves improved accuracy by incorporating information about potential long-range interactions.
Yang Young Lu and William Staford Noble
The triumphs and limitations of computational methods for scRNA-seq | Nature Methods
November 10, 2021Liked this @KharchenkoLab review – in particular, the descriptions of the various low-dimensional approximations & the simple motivation for these using PCA. Also, found the step-by-step workflow in the text & figures helpful.
Note also the reference to expression entropy for determining the direction in trajectories.
Review Article
Published: 21 June 2021
The triumphs and limitations of computational methods for scRNA-seq
Peter V. Kharchenko
Nature Methods volume 18, pages723–732 (2021)
Weighing wastewater’s worth as a COVID-19 monitoring tool
October 24, 2021A perfect storm for container shipping | The Economist
October 2, 2021QT:{{
The spot price for sending such a box from Shanghai to New York, which in 2019 would have been around $2,500, is now nearer $15,000. Securing a late booking on the busiest route, from China to the west coast of America, could cost $20,000.
…
Some observers think normality may return after Chinese new year next February. Peter Sand of bimco says disruptions could even take a year to unwind. Lars Jensen of Vespucci Maritime, an advisory firm, notes that a dockers’ strike on America’s west coast in 2015 caused similar disruption, albeit only in the region. It still took six months to unwind the backlog.
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https://www.economist.com/finance-and-economics/a-perfect-storm-for-container-shipping/21804500
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