A gene sequence-to-expression machine learning model achieves improved accuracy by incorporating information about potential long-range interactions.
Yang Young Lu and William Staford Noble
A gene sequence-to-expression machine learning model achieves improved accuracy by incorporating information about potential long-range interactions.
Yang Young Lu and William Staford Noble
Liked this @KharchenkoLab review – in particular, the descriptions of the various low-dimensional approximations & the simple motivation for these using PCA. Also, found the step-by-step workflow in the text & figures helpful.
Note also the reference to expression entropy for determining the direction in trajectories.
Review Article
Published: 21 June 2021
The triumphs and limitations of computational methods for scRNA-seq
Peter V. Kharchenko
Nature Methods volume 18, pages723–732 (2021)
QT:{{
The spot price for sending such a box from Shanghai to New York, which in 2019 would have been around $2,500, is now nearer $15,000. Securing a late booking on the busiest route, from China to the west coast of America, could cost $20,000.
…
Some observers think normality may return after Chinese new year next February. Peter Sand of bimco says disruptions could even take a year to unwind. Lars Jensen of Vespucci Maritime, an advisory firm, notes that a dockers’ strike on America’s west coast in 2015 caused similar disruption, albeit only in the region. It still took six months to unwind the backlog.
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https://www.economist.com/finance-and-economics/a-perfect-storm-for-container-shipping/21804500
https://www.cell.com/ajhg/fulltext/S0002-9297(16)30526-2
Expanding Access to Large-Scale Genomic Data While Promoting Privacy: A Game Theoretic Approach
Zhiyu Wan
Yevgeniy Vorobeychik
Weiyi Xia
Ellen Wright Clayton
Murat Kantarcioglu
Bradley Malin
Published:January 05, 2017
DOI:https://doi.org/10.1016/j.ajhg.2016.12.002
QT:{{”
To understand why screens often have little effect on protecting people from aerosol particles, it helps to think about exhaled breath like a plume of cigarette smoke, Dr. Marr said.
“One way to think about plastic barriers is that they are good for blocking things like spitballs but ineffective for things like cigarette smoke,” Dr. Marr said. “The smoke simply drifts around them, so they will give the person on the other side a little more time before being exposed to the smoke. Meanwhile, people on the same side with the smoker will be exposed to more smoke, since the barriers trap it on that side until it has a chance to mix throughout the space.” “}}
Another useful fact connected to this thread is that secondhand cigarette smoke is a good indicator of aerosol behavior
https://www.nhregister.com/opinion/article/Opinion-What-secondhand-smoke-tells-us-about-the-15794467.php viz: https://twitter.com/MarkGerstein/status/1430324404752318464
https://www.nytimes.com/2021/08/19/well/live/coronavirus-restaurants-classrooms-salons.html