https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009444
Archive for the 'SciLit' Category
motif discovery on personal genomes
October 9, 2021Navigating the new era of assisted suicide and execution drugs | Journal of Law and the Biosciences | Oxford Academic
October 2, 2021https://academic.oup.com/jlb/article/4/2/424/4265564
QT:{{”
Meanwhile, the standard PAS protocol in the USA involves the prescription of a lethal dose of a barbiturate, typically
pentobarbital or secobarbital, to be consumed by the patient in liquid form. Often, the dose is mixed with juice, in what is often called a ‘potion’, to combat the bitter taste of the drugs. The patient is legally required to drink the potion by themselves, to ensure the decision remains autonomous. Physicians are free to prescribe, off-label, any drug they deem fit for these lethal purposes, under protection from prosecution. Only three lethal medications
(secobarbital, pentobarbital, and phenobarbital) have been used, according to state statistics, aside from anti-nausea and anti-anxiety medications to combat side effects.5 In the Netherlands and Belgium, physicians typically rely on sodium thiopental and pancuronium bromide when euthanizing patients at their behest.13
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Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors | Nature Biotechnology
September 25, 2021https://www.nature.com/articles/s41587-021-01024-0
An easily swallowed capsule injects drugs straight into the gut https://www.nature.com/articles/d41586-021-02443-4
Using deep learning to model the hierarchical structure and function of a cell | Nature Methods
September 18, 2021https://www.nature.com/articles/nmeth.4627
interpretable deep learning model
Expanding Access to Large-Scale Genomic Data While Promoting Privacy: A Game Theoretic Approach: The American Journal of Human Genetics
August 29, 2021https://www.cell.com/ajhg/fulltext/S0002-9297(16)30526-2
Expanding Access to Large-Scale Genomic Data While Promoting Privacy: A Game Theoretic Approach
Zhiyu Wan
Yevgeniy Vorobeychik
Weiyi Xia
Ellen Wright Clayton
Murat Kantarcioglu
Bradley Malin
Published:January 05, 2017
DOI:https://doi.org/10.1016/j.ajhg.2016.12.002
fermented foods
August 28, 2021How Fermented Foods May Alter Your Microbiome and Improve Your Health
https://www.nytimes.com/2021/08/13/well/eat/yogurt-kimchi-kombucha-microbiome.html
Foods like yogurt, kimchi, sauerkraut and kombucha increased the diversity of gut microbes and led to lower levels of inflammation.
ARTICLE| VOLUME 184, ISSUE 16, P4137-4153.E14, AUGUST 05, 2021
https://www.cell.com/cell/fulltext/S0092-8674(21)00754-6
Gut-microbiota-targeted diets modulate human immune status
Hannah C. Wastyk 7
Gabriela K. Fragiadakis 7
Dalia Perelman
Dylan Dahan
Bryan D. Merrill
Feiqiao B. Yu
Madeline Topf
Carlos G. Gonzalez
William Van Treuren
Shuo Han
Jennifer L. Robinson
Joshua E. Elias
Erica D. Sonnenburg
Christopher D. Gardner
Justin L. Sonnenburg 8
Published:July 12, 2021
Bioanalogous Properties of Blockchains
August 14, 2021https://link.springer.com/article/10.1007/s11084-021-09608-1
Emergent Bioanalogous Properties of Blockchain-based Distributed Systems
Oleg Abramov, Kirstin L. Bebell & Stephen J. Mojzsis
Origins of Life and Evolution of Biospheres (2021)
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes | Science
July 17, 2021https://science.sciencemag.org/content/369/6510/1501
BY CHING-LIN HSIEH, JORY A. GOLDSMITH, JEFFREY M. SCHAUB, ANDREA M. DIVENERE, HUNG-CHE KUO, KAMYAB JAVANMARDI, KEVIN C. LE, DANIEL WRAPP, ALISON G. LEE, YUTONG LIU, CHIA-WEI CHOU, PATRICK O. BYRNE, CHRISTY K. HJORTH, NICOLE V. JOHNSON, JOHN LUDES-MEYERS, ANNALEE W. NGUYEN, JUYEON PARK, NIANSHUANG WANG, DZIFA AMENGOR, JASON J. LAVINDER, GREGORY C. IPPOLITO, JENNIFER A. MAYNARD, ILYA J. FINKELSTEIN, JASON S. MCLELLAN
SCIENCE18 SEP 2020 : 1501-1505
The design of stabilizing mutations in the SARS-CoV-2 spike protein allows for high-yield production of a critical vaccine antigen.
In particular,
stabilization is very important for the Moderna vaccine design.
This work builds on :
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Science. 2013 Nov 1;342(6158):592-8. doi: 10.1126/science.1243283.
Structure-based design of a fusion glycoprotein vaccine for
respiratory syncytial virus
Jason S McLellan 1, Man Chen, M Gordon Joyce, Mallika Sastry, Guillaume B E Stewart-Jones, Yongping Yang, Baoshan Zhang, Lei Chen, Sanjay Srivatsan, Anqi Zheng, Tongqing Zhou, Kevin W Graepel, Azad Kumar, Syed Moin, Jeffrey C Boyington, Gwo-Yu Chuang, Cinque Soto, Ulrich Baxa, Arjen Q Bakker, Hergen Spits, Tim Beaumont, Zizheng Zheng, Ningshao Xia, Sung-Youl Ko, John-Paul Todd, Srinivas Rao, Barney S Graham, Peter D Kwong
Affiliations expand
PMID: 24179220 PMCID: PMC4461862 DOI: 10.1126/science.1243283 https://pubmed.ncbi.nlm.nih.gov/24179220/
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