Posts Tagged ‘Elysium’
The Longevity Business Is Booming—and Its Scientists Are Clashing – WSJ
March 30, 2025https://www.wsj.com/health/wellness/longevity-antiaging-leonard-guarente-business-f55643f4
Marcus, A. D. (2025, March 23). The longevity business is booming—and its scientists are clashing. WSJ.
The Abstract: 8 Compounds That Target Aging
March 18, 2025Guarente, L., Sinclair, D. A., & Kroemer, G. (2024). Human trials exploring anti-aging medicines. Cell Metabolism, 36(2), 354–376. https://doi.org/10.1016/j.cmet.2023.12.007
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00458-8
QT:{{”
In a recent issue of Cell Metabolism, Guarente co-authored a review article about human trials exploring compounds that target pathways and mechanisms of aging along with David Sinclair, Ph.D., one of Dr. Guarente’s postdoctoral mentees and now a professor of genetics at Harvard Medical School, and Guido Kroemer, M.D., Ph.D., a professor at the Université Paris Cité. Guarente and his colleagues focus on eight drugs and compounds: metformin, NAD+ precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatories.
These interventions made the list for four reasons: 1) they’re well-represented in ongoing or completed human clinical trials; 2) they’ve been shown to slow aging in preclinical studies; 3) they’re thought to be sufficiently safe for long-term use in humans; and 4) they work by targeting the hallmarks of aging.
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Is Biological Age Testing Accurate or Useful? – The New York Times
December 15, 2024Anti-ageing pill pushed as bona fide drug
July 4, 2017QT:{{‘
“Current treatments for diseases related to ageing “just exchange one disease for another”, says physician Nir Barzilai of the Albert Einstein College of Medicine in New York. That is because people treated for one age-related disease often go on to die from another relatively soon thereafter. “What we want to show is that if we delay ageing, that’s the best way to delay disease.”
Barzilai and other researchers plan to test that notion in a clinical trial called Targeting Aging with Metformin, or TAME. They will give the drug metformin to thousands of people who already have one or two of three conditions — cancer, heart disease or cognitive impairment — or are at risk of them. People with type 2 diabetes cannot be enrolled because metformin is already used to treat that disease.
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http://www.nature.com/news/anti-ageing-pill-pushed-as-bona-fide-drug-1.17769
Can we hit the snooze button on aging? | March 6, 2017 Issue – Vol. 95 Issue 10 | Chemical & Engineering News
April 23, 2017Can we hit the snooze button on #aging?
http://CEN.acs.org/articles/95/i10/hit-snooze-button-aging.html Various ways to tackle this timeless issue; for me more pertinent by the day
Silicon Valley’s Quest to Live Forever
April 10, 2017SV’s Quest to Live Forever
http://www.NewYorker.com/magazine/2017/04/03/silicon-valleys-quest-to-live-forever Cal. restriction to #Singularity: Immortalists v Healthspanners, Meat Puppets v RoboCops
QT:{{”
“Immortalists fall into two camps. Those who might be called the Meat Puppets, led by de Grey, believe that we can retool our biology and remain in our bodies. The RoboCops, led by Kurzweil, believe that we’ll eventually merge with mechanical bodies and/or with the cloud. Kurzweil is a lifelong fixer and optimizer: early in his career, he invented the flatbed scanner and a machine that reads books aloud to the blind. Those inventions have improved dramatically in subsequent iterations, and now he’s positive that what he calls “the law of accelerating returns” for human longevity is about to kick in.”
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“The battle between healthspanners and immortalists is essentially a contest between the power of evolution as ordained by nature and the potential power of evolution as directed by man. The healthspanners see us as subject to linear progress: animal studies take the time that they take; life sciences move at the speed of life. Noting that median life expectancy has been increasing in developed nations by about two and a half years a decade, Verdin told me, “If we can keep that pace up for the next two hundred years, and increase our life spans by forty years, that would be incredible.”
The immortalists have a different view of both our history and our potential. They see centuries of wild theorizing (that aging could be reversed by heating the body, or by breathing the same air as young virgins) swiftly replaced by computer-designed drugs and gene therapies. Bill Maris said, “Health technology, which for five thousand years was symptomatic and episodic—‘Here are some
leeches!’—is becoming an information technology, where we can read and edit our own genomes.”
Many immortalists view aging not as a biological process but as a physical one: entropy demolishing a machine. And, if it’s a machine, couldn’t it be like a computer?
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“And yet. Last year, the geneticist Nir Barzilai hosted a screening of a documentary about longevity, and afterward he posed a question to the three hundred people in the audience. He told me, “I said, ‘In nature, longevity and reproduction are exchangeable. So Choice One is, you are immortalized, but there is no more reproduction on Earth, no pregnancy, no first birthday, no first love’—and I go on and on and on.” He laughed, amused by his own determination to load the dice. “ ‘Choice Two,’ I said, ‘is you live to be eighty-five and not one day sick, everything healthy and fine, and then one morning you just don’t wake up.” The vote was decisive, he said. “Choice One got ten or fifteen people. Everyone else raised their hands for Choice Two.”
This wish to preserve life as we know it, even at the cost of dying, is profoundly human. We are encoded”
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Dietary supplements: Nobel or ignoble – The Boston Globe
April 3, 2017Pterostilbene – Scientific Review on Usage, Dosage, Side Effects | Examine.com
March 20, 2017https://examine.com/supplements/pterostilbene/
QT:{{"
Low doses of pterostilbene (for a human, 10mg or less usually) seem to hold some benefit for cognition, and are thought to be one of the bioactive components of blueberries (alongside the anthocyanin content). Higher doses may not have said neurological effects, but higher supplemental dosages of pterostilbene (in the 250-500mg range usually) seem to have benefit for reducing cholesterol and glucose in research animals. The reduction in blood glucose and improvement in insulin sensitivity is quite potent, with a few studies noting that it is comparable to metformin as the reference drug.
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