Genome-Scale Signatures of Gene Interaction from #CompoundScreens Predict…Efficacy of Targeted Cancer Therapies
https://www.ScienceDirect.com/science/article/pii/S2405471218300097 How to find drug combos: Find expression response profiles associated w/ a drug target. A synergistic drug might change profiles similarly
Posts Tagged ‘from’
Genome-Scale Signatures of Gene Interaction from Compound Screens Predict Clinical Efficacy of Targeted Cancer Therapies – ScienceDirect
April 28, 2018Cryo-EM structure of substrate-bound human telomerase holoenzyme | Nature
April 28, 2018#CryoEM structure of substrate-bound human telomerase holoenzyme https://www.Nature.com/articles/s41586-018-0062-x Quote: “2 flexibly RNA-tethered lobes: the catalytic core (w/ #TERT & conserved motifs of telomerase RNA) & an H/ACA RNP”
Augmented reality for macromolecule viewing
April 22, 2018Incredible Android app for AR viewing of macromolecules http://CIRC.Rutgers.edu/new-dimension-poster-presentation Especially neat when pointed at another phone or tablet. Shows the molecule literally coming out of the screen HT @gamzeandgursoy
an app that might be interesting: When you look at the molecule pictures that are called triggers through this
app, it shows them three dimensional in different angles. You can even
create movie type augmented realities.
systematic comparison of dnase-seq & atac-seq
April 21, 2018Reproducible inference of TF footprints in #ATACseq & DNase-seq…via protocol-specific bias modeling
https://www.BiorXiv.org/content/early/2018/03/19/284364 Systematic comparison of the 2 assay HT @gamzeandgursoy
Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression | eLife
April 21, 2018Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression https://eLifeSciences.org/articles/25125 More noncoding than coding #allelic activity. Also, finding windows of allelic activity for chromatin
Daniel Andergassen,
Christoph P Dotter,
Daniel Wenzel,
Verena Sigl,
Philipp C Bammer,
Markus Muckenhuber,
Daniela Mayer,
Tomasz M Kulinski,
Hans-Christian Theussl,
Josef M Penninger,
Christoph Bock,
Denise P Barlow ,
Florian M Pauler ,
Quanah J Hudson
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria;
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria;
Institute of Molecular Pathology, Austria
Could baby’s first bacteria take root before birth?
April 21, 2018Could baby’s first bacteria take root before birth?
https://www.Nature.com/articles/d41586-018-00664-8 Interesting discussion of the controversy around detecting trace exogenous sequences in human tissues. Perhaps relevant to #exRNA?
Need to make a molecule? Ask this AI for instructions
April 7, 2018Need to make a molecule? Ask this AI for instructions
http://www.nature.com/articles/d41586-018-03977-w #DeepLearning to do better #retrosynthesis. Perhaps other things in chemistry could be learned as well!
QT:{{”
“The tool, described in Nature on 28 March1, is not the first software to wield artificial intelligence (AI) instead of human skill and intuition. Yet chemists hail the development as a milestone, saying that it could speed up the process of drug discovery and make organic chemistry more efficient.
“What we have seen here is that this kind of artificial intelligence can capture this expert knowledge,” says Pablo Carbonell, who designs synthesis-predicting tools at the University of Manchester, UK, and was not involved in the work. He describes the effort as “a landmark paper”.”
“}}
info theory book by Cover&Thomas
April 5, 2018Need to make a molecule? Ask this AI for instructions
April 1, 2018Lady M
March 24, 201841 East 78th St
Monday to Friday: 10am-7pm
Saturday: 11am-7pm
Sunday: 11am-6pm
https://www.ladym.com/boutiques
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