https://www.fda.gov/drugs/drug-safety-communications/fda-requires-boxed-warning-about-serious-mental-health-side-effects-asthma-and-allergy-drug QT:{{” We continue to receive reports of mental health side effects reported with montelukast use. Consistent with our prior evaluations, a wide variety of mental health side effects have been reported, including completed suicides. Some occurred during montelukast treatment and resolved after stopping the medicine. Other reports indicated that mental health side effects developed or continued after stopping montelukast. The Sentinel study, which studied asthma patients 6 years and older, and other observational studies did not find an increased risk of mental health side effects with montelukast compared to inhaled corticosteroids (ICS). However, the Sentinel study and the observational studies had some limitations which may affect how we interpret the results. We also reviewed animal studies, which showed that montelukast given orally reaches the brain in rats.1 (See Data Summary for more information) “}}
Posts Tagged ‘to’
Diphenhydramine-induced toxic psychosis – PubMed
May 28, 2026https://pubmed.ncbi.nlm.nih.gov/3718632/
QT:{{” A 24-year-old man presented to the emergency department with acute anticholinergic symptoms, hallucinations, and bizarre behavior following a large ingestion of diphenhydramine (Benadryl). “}}
benadryl can cross BBB & cause delusions
Amazon.com: ndd Medical Technologies 2500-2A EasyOne Air Spirometer System () : Industrial & Scientific
May 10, 2026The Longevity Secrets Helping Athletes Blow Past the Limits of Age
May 8, 2026sports: money, data & fun
QT:{{”
Partly what’s driving the changes is the size of the fortunes at stake. The typical salary for an N.B.A. player is now close to $12 million a year. Career reserves — not just the stars — often employ their own trainers, dietitians, chefs and assortments of recovery gizmos. When a member of James’s inner circle claimed in 2018 that James was spending about $1.5 million a year on caring for his body, it accelerated an arms race across sports, helping to power a consumer-tech boom that has already trickled down to the $314 billion market for wearable devices that track things like sleep and heart rate.
….
Today’s pros are awash in data, and the ones who learn to sort out the signals from the noise stand the best chance of prolonging their careers.
…
Most of that data is still noise. “Just because you can measure it” — using wearable devices, for example — “doesn’t mean it’s meaningful, durable, that kind of thing,” says Dr. Michael Joyner, a specialist in the physiology of elite athletes at the Mayo Clinic. The most useful data so far, he says, speaking for himself and not the clinic, relates to “load management”: monitoring exertion, particularly by older players, to reduce the risk of fatigue-related, noncontact injuries. …
Since 2021, the N.B.A. has run an in-house incubator called Launchpad that collaborates annually with five small start-ups whose projects might prove useful to the league — an A.I. tool to track officiating, say, or a device that converts gameplay into haptics for
sight-impaired fans.
….
As part of the effort to collect joint and muscle data, every single N.B.A. player, from LeBron to Bronny, now takes a brief “biomechanical assessment” up to four times a year. The assessment room I visited, at the Brooklyn Nets facility, looked like a miniature Marvel movie set — bright space, blank walls, a ring of cameras to capture motion — only this room had two “force plates” built into the floor that help measure applied muscle force.
The assessment covers seven simple movements — various lunges, jumps and timed balances — and produces a player score relative to the rest of the league and the player’s own history.
….
For some athletes, the right biometric data presented in the right context represents “permission to rest,” says Ana Montero, a co-founder of Atlas, a San Francisco-based company that makes brain-wave-scanning, behind-the-ear wearables about the size of Mentos candies. “It’s quantifiable evidence that is showing you: Dude, today — or right now — is not the day. Go to the gym, go for a walk, go for whatever it is. And then coming back and actually seeing that you’ve bounced back.”
The Atlas device gathers several types of data, including
electroencephalography, or EEG, which measures electrical activity in the brain, and galvanic skin response, or G.S.R., which is what a polygraph test measures. That data is sorted into five categories (among them agility, vitality and stress) and then delivered with advice through a smartphone app.
“}}
Book Review: ‘Open Space,’ by David Ariosto – The New York Times
May 3, 2026https://www.nytimes.com/2026/03/24/books/review/open-space-david-ariosto.html?unlocked_article_code=1.VlA.HACP.bzbyut-McnKU a rare book review that’s fairly critical – not positive
EXTRASTAMINA on X: “Relax https://t.co/JAYyvOOHWc” / X
May 2, 2026https://x.com/videothread3/status/2049865903819358324
Wonder if it’d be good to do one for slitting
4 Drugs That May Increase Your Dementia Risk
April 28, 2026QT:{{”
Antihistamines
The class of medications with perhaps the most evidence of raising dementia risk are called anticholinergics. ….
“That once-in-a-while use of Benadryl is unlikely to increase risk for dementia,” Dr. Gray said. …
So-called second generation antihistamines, like Claritin and Zyrtec, don’t have anticholinergic activity, so they can be a safer option for seasonal allergies,
Antipsychotic Drugs
With mental health medications and dementia, there is a chicken-or-egg question: Do the drugs themselves increase the risk of dementia, or is it the conditions the drugs are prescribed for, such as depression or psychosis, that increase it? ….
Benzodiazepines
These mental health medications, which work on a specific
neurotransmitter to suppress brain activity, have also been linked to dementia…..
Proton Pump Inhibitors
Conflicting evidence has also been reported about proton pump inhibitors, which are often used to treat acid reflux. … Some proton pump inhibitors, like Prilosec, are purchased over the counter, so their use can be more difficult to track and analyze than prescription medications.
“}}
The New York Times
https://www.nytimes.com/2026/04/22/well/mind/medications-dementia-risk-increase.html
A mechanism for adaptive genome regulation in cancer | Nature
April 25, 2026https://www.nature.com/articles/s41586-026-10269-1
Nice discussion of discrete cell types v cont. cell states
QT:{{”
Although the transcriptomic classification of cell types and states into discrete hierarchical entities is useful for standardizing and recogniz- ing functional units8, this framework could risk the reinforcement of a Platonic view, in which observed states are viewed as approximations to idealized configurations underpinned by strict gene programs (Fig. 1a). The advent of single-cell RNA sequencing has provided evidence for the notion that cells often traverse continuous and multidimensional landscapes of gene expression, shaped by varying degrees of constraint and plasticity. Such dynamics are an inherent cellular attribute that also occurs in seemingly stable physiological states, and processes in normal physiology once thought to involve binary choices are now recognized as continuous (Fig. 1b). For example, haematopoiesis reflects gradual acquisition of lineage biases rather than transitions between discrete progenitor states9. Epithelial-to-mesenchymal transition (EMT) proceeds through multiple intermediate hybrid states with context-specific tran- scriptional profiles10. Waddington’s well-known epigenetic landscape metaphor, where cells roll down a fixed, branching landscape during cell-fate decisions and settle at valleys corresponding to stable inter- mediate or terminally differentiated states, may not fully capture the continuity of cellular-state transitions11. Instead, the landscape itself appears to be flexible, especially in disease contexts, with environmental and genetic changes reshaping the accessibility of states, thus changing the barriers that govern cell-state transitions (Fig. 1c). “}}
França, G. S., & Yanai, I. (2026). A mechanism for adaptive genome regulation in cancer. Nature, 652(8110), 581–590.
https://doi.org/10.1038/s41586-026-10269-1
Zebrafish reveal new insights into the biology of autism | Yale News
April 20, 2026https://news.yale.edu/2026/04/02/zebrafish-reveal-new-insights-biology-autism?utm_source=YaleToday&utm_medium=email&utm_campaign=YT_YaleToday-Faculty_4-7-2026 QT{{” Here, we leverage the strengths of zebrafish as a scalable in vivo system to screen 520 US FDA-approved drugs and establish a database of their effects on sensory processing and arousal behaviors. Using this database, we nominate pharmacological candidates relevant to specific ASD genes or gene subgroups. “}}
Jamadagni, P., Dai, Y., Liu, Y., Mendes, H. W., Pruitt, A., Khan, S., Yang, L., Huang, T., Huang, X., Deans, P. J. M., Balafkan, N., Zhao, D., Xu, G., Liu, Y., Li, N., Wu, W., Fitzpatrick, S. E., Neelakantan, U., Chen, T., . . . Hoffman, E. J. (2026). Pharmaco-behavioral profiling identifies suppressors of autism gene–associated phenotypes in zebrafish. Proceedings of the National Academy of Sciences, 123(12), e2518846123. https://doi.org/10.1073/pnas.2518846123
linkstream2 microblog 