Genes, environment & bad luck
http://science.ScienceMag.org/content/355/6331/1266 To what degree are #cancer mutations due to replication error (3rd factor), not 1st 2?
discusses R v D correlation
Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention Cristian Tomasetti1,2,*, Lu Li2, Bert Vogelstein3,*
Science 24 Mar 2017:
Vol. 355, Issue 6331, pp. 1330-1334
DOI: 10.1126/science.aaf9011
http://science.sciencemag.org/content/355/6331/1330
Education in #CompBio, by @bffo & @joannealisonfox
http://journals.PLOS.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003391 Keeping up in a rapidly changing field. Will implement some @Yale
QT:{{”
“These initiatives help to extend computational biology beyond the domain of specialized laboratories. Researchers, at all levels, need to keep themselves up-to-date with the quickly changing world of computational biology, and trainees need programs where bioinformatics skills are embedded so they can have comprehensive training. New bioinformatics workflows can be adopted more widely if education efforts keep pace. As previously pointed out , starting early is also very important. There is still room for programs that capture the excitement and enthusiasm of secondary school students and convey the potential of computational biology to the public. We welcome additions to the PLOS Computational Biology “Bioinformatics: Starting Early” collection (www.ploscollections.org/cbstartingearly).
We would like to involve the community in this endeavor. With this editorial, we are calling out to educators and researchers who have experience in teaching, specifically, those keen to raise the expectations and the inquisitiveness of the next generation of biologists. The Education collection will continue to publish leading edge education materials in the form of tutorials that can be used in a “classroom” setting (whatever that may mean nowadays: stated more generically, “the places where people learn”). We will continue to encourage articles set in the context of addressing a particular biological question and, as mentioned above, we welcome new “primers” and “quick guides.” We will also be inviting tutorials from the various computational meetings. A new category of papers that is in the pipeline for the Education collection is the “Quick Tips” format, the first of which was just published . The “Quick Tips” articles address specific tools or databases that are in wide use in the community.
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Mutation mapping & identification by WGS
http://Genome.CSHLP.org/content/22/8/1541 SNPtrack server, for uploading reads, does #SNP calls & prioritization
This is a novel method for genetic mapping of mutations.
It accomplishes (1) SNP discovery, (2) mutation localization (including
enumerating allele distribution, assessing recombination breakpoint), and
(3) identifying potential causal variants.
In contrast to previous approaches, this method implemented a HMM model
which does not rely on prior knowledge of SNP variation. The HMM model
predicts the recombination events/breakpoints in increasing distance from
the homozygous SNP sites over whole genome.
Software available: SNPtrack
http://genetics.bwh.harvard.edu/snptrack
Leshchiner I, Alexa K, Kelsey P, Adzhubei I, Austin C, Cooney J, Anderson H, King M, Stottmann RW, Ha S, Drummond I, Paw BH, North T, Beier D, Goessling W, Sunyaev S. Mutation mapping and identification by whole genome sequencing. Genome Research (2012) 22: 1541-1548.
Recombined allele of..lipase gene CEL & its #pseudogene CELP confers susceptibility to..pancreatitis
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3249.html CEL-HYB chimera
Is American Pet Health Care (Also) Uniquely Inefficient?
http://www.NBER.org/papers/w22669 High correlation betw. #healthcare costs for people & pets
Function of the FFL network motif
http://www.PNAS.org/content/100/21/11980.abstract Decade-old work defining coherent & incoherent ones based on activation/repression
http://sites.fas.harvard.edu/~mcb195/lectures/Networks-II/Literature/pnas_Mangan03.pdf
#Brain Insights from Cochlear Implants
http://www.americanscientist.org/blog/pub/new-brain-insights-from-cochlear-implants Soundtracks simulating the voice of implant based on 1 sided deaf patients
QT:{{”
An additional insight provided by single-sided deaf patients is that they allow us, for the first time, to objectively determine the “voice” of an implant. That’s because these patients can compare how speech sounds through their cochlear implant with what they hear in their normal-hearing ear.”
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Transmissible Dog Cancer Genome Reveals…History of an Ancient Cell Lineage http://science.sciencemag.org/content/343/6169/437.full After 11k yrs 2M SNVs & 646 genes KO’ed
Elizabeth P. Murchison1,2,*,†,
David C. Wedge1,*,
Ludmil B. Alexandrov1,
Beiyuan Fu1,
Inigo Martincorena1,
Zemin Ning1,
Jose M. C. Tubio1,
Emma I. Werner1,
Jan Allen3,
Andrigo Barboza De Nardi4,
Edward M. Donelan3,
Gabriele Marino5,
Ariberto Fassati6,
Peter J. Campbell1,
Fengtang Yang1,
Austin Burt7,
Robin A. Weiss6,
Michael R. Stratton1,†
+ See all authors and affiliations
Science 24 Jan 2014:
Vol. 343, Issue 6169, pp. 437-440
DOI: 10.1126/science.1247167
TP53 copy number expansion is associated w…enhanced DNA damage response in elephants https://elifesciences.org/content/5/e11994 18 p53 retro- & pseudo- genes
#BigData: Astronomical or Genomical?
http://journals.PLOS.org/plosbiology/article?id=10.1371/journal.pbio.1002195 Est. current storage in EB/yr: Astro .1, omics .1, Twitter .001, YouTube .1-1
QT:{{”
“Data storage requirements for all four domains are projected to be enormous. Today, the largest astronomy data center devotes ~100 petabytes to storage, and the completion of the Square Kilometre Array (SKA) project is expected to lead to a storage demand of 1 exabyte per year. YouTube currently requires from 100 petabytes to 1 exabyte for storage and may be projected to require between 1 and 2 exabytes additional storage per year by 2025. Twitter’s storage needs today are estimated at 0.5 petabytes per year, which may increase to 1.5 petabytes in the next ten years. (Our estimates here ignore the “replication factor” that multiplies storage needs by ~4, for redundancy.) For genomics, we have determined more than 100 petabytes of storage are currently used by only 20 of the largest institutions ().”
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linkstream2 microblog 