Elucidating Molecular Motion (compatible w. #NMR relaxation times) through…Filters of Energy-Minimized…Ensembles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983377
Archive for the 'SciLit' Category
Elucidating Molecular Motion through Structural and Dynamic Filters of Energy-Minimized Conformer Ensembles
September 30, 2016PLOS ONE: Sizing the Problem of Improving Discovery and Access to NIH-Funded Data: A Preliminary Study
September 29, 2016High-throughput discovery of novel developmental phenotypes : Nature : Nature Research
September 22, 2016HTP discovery of novel developmental #phenotypes
http://www.nature.com/nature/journal/v537/n7621/full/nature19356.html New list of essential genes for the mouse, upping number to ~2900
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer | Science
September 19, 2016high mutational burden predicts responsive patients
Inferring regulatory element landscapes and transcription factor networks from cancer methylomes | Genome Biology | Full Text
September 19, 2016The Path to Cancer — Three Strikes and You’re Out — NEJM
September 18, 2016Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. – PubMed – NCBI
September 18, 2016PETModule: a motif module based approach for enhancer target gene prediction : Scientific Reports
September 17, 2016PETModule…enhancer-target-gene prediction
http://www.nature.com/articles/srep30043 Compares activity
correlations against a Hi-C/ChIA-PET gold std.
Cancer undefeated. – PubMed – NCBI
September 11, 2016http://www.ncbi.nlm.nih.gov/pubmed/9164814
Bailar JC 3rd1, Gornik HL.NEJM
QT:{{"
Despite decades of basic and clinical research and trials of promising new therapies, cancer remains a major cause of morbidity and mortality. We assessed overall progress against cancer in the United States from 1970 through 1994 by analyzing changes in age-adjusted mortality rates."}}
Treatment of Acute Lymphoblastic Leukemia — 30 Years’ Experience at St. Jude Children’s Research Hospital — NEJM
September 11, 2016http://www.nejm.org/doi/full/10.1056/NEJM199310283291801#t=article
QT:{{”
When treated with effective multiagent chemotherapy, about two thirds of children with newly diagnosed acute lymphoblastic leukemia survive for long periods of time1-4. Much of this success can be credited to more intensive early treatment, especially of patients at higher risk of relapse.
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Result of Pinkel ’79 study
linkstream2 microblog 