Posts Tagged ‘from’

DNA Tattoos Are the Final Frontier of Love

December 18, 2017

DNA Tattoos Are the Final Frontier of Love
https://www.NYTimes.com/2017/12/09/style/dna-tattoos.html Putting some DNA into tattoo ink via @Everence_Life. But what of putting tattoos into non-functional DNA with CRISPR? Maybe next? HT @gamzeandgursoy

QT:{{
Four years, a handful of dedicated colleagues and nearly a dozen patents later, Mr. Duffy has brought the idea to life with Everence, a product he and his partners hope will deepen bonds — in the most literal and physical way — between family, friends and loved ones. It is about as biologically intimate as one can get. Everence is a powdery substance synthesized from a sample of DNA, something as simple as a few thousand cells from a swab of a person’s inner cheek, or from cremated ashes. A small vial of Everence can be brought to a tattoo artist and added to any type of inks.
The result: A tattoo imbued with the DNA of another human being — or, if you prefer, a dog, cat or other furry friend.
In so doing, Mr. Duffy and Endeavor Life Sciences, his company, join the ranks of a winding list of biohackers, artists and technologists dabbling in the world of biogenic tattoo artistry. Many have mixed ash, hair or other material with inks to include organics in tattooing for years.
“}}

google released variant calling with deep learning

December 16, 2017

$GOOG Is Giving Away AI That Can Build Your Genome Seq. https://Research.GoogleBlog.com/2017/12/deepvariant-highly-accurate-genomes.html + https://www.Wired.com/story/google-is-giving-away-ai-that-can-build-your-genome-sequence GATK creators now doing a tensor-flow version. Release sounded a bit like IBM unveiling Deep Blue decades ago: “Today, we announce…DeepVariant, a #DeepLearning tech…"

Steven Salzberg’s response to deep variant:
https://www.forbes.com/sites/stevensalzberg/2017/12/11/no-googles-new-ai-cant-build-your-genome-sequence/#5953db7b5774

QT:{{"On Monday, Google released a tool called DeepVariant that uses deep learning—the machine learning technique that now dominates AI—to identify all the mutations that an individual inherits from their parents.1 Modeled loosely on the networks of neurons in the human brain, these massive mathematical models have learned how to do things like identify faces posted to your Facebook news feed, transcribe your inane requests to Siri, and even fight internet trolls. And now, engineers at Google Brain and Verily (Alphabet’s life sciences spin-off) have taught one to take raw sequencing data and line up the billions of As, Ts, Cs, and Gs that make you you.”
"}}

Google Is Giving Away AI That Can Build Your Genome Sequence
https://www.wired.com/story/google-is-giving-away-ai-that-can-build-your-genome-sequence/

Behind the Murdochs’ Sale Talks: Scale, Price and Family Dynamics – WSJ

December 16, 2017

Behind the Murdochs’ Sale Talks: Scale, Price & Family Dynamics
https://www.wsj.com/articles/behind-the-murdochs-sale-talks-scale-price-and-family-dynamics-1512521082 Walking on eggshells: @WSJ reporting on a family that owns the paper & its plans to sell part of its empire

New Haven, CT Electricity Rates | Electricity Local

December 11, 2017

Useful
https://www.electricitylocal.com/states/connecticut/new-haven/

Batch Cloud Data Transfer Services – Amazon Snowball Appliance

December 9, 2017

Batch Cloud Data Transfer for @AWScloud
https://AWS.amazon.com/snowball & https://AWS.amazon.com/snowmobile Snail mail trumps email for really large data. Interesting to calculate effective transfer rates as compared “Ethernet.” Surprised that I couldn’t find even crude estimates.

Toddler steals the show and gives away mom’s M.D. – YouTube

December 7, 2017

https://www.youtube.com/watch?v=6DLWNdjqPC8

NYTimes: A Seasonal Business Means Year-Round Work, but a Smaller Profit Window

December 5, 2017

https://www.nytimes.com/2017/11/24/your-money/seasonal-business.html

Evogeneao: The Tree of Life

December 2, 2017

Evogeneao: The Tree of Life
https://www.evogeneao.com/explore/tree-of-life-explorer Nice web tool. Particularly good for interactively #visualizing human #evolution relative to that of other species

Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating – ScienceDirect

November 30, 2017

QT:{{”
• Find 3.8 Å resolution cryo-EM structure of the ∼200 kDa magnesium channel CorA • Mg2+-free CorA exhibits dramatic loss of symmetry in the cytoplasmic domain …
• Inter-subunit Mg2+ is important for stabilizing the closed state of CorA “}}

#CryoEM Structures of the Mg++ Channel CorA Reveal Symmetry Break upon Gating https://www.ScienceDirect.com/science/article/pii/S0092867415017195 In closed conformation: 5 identical subunits arranged tightly around 5-fold axis & pore. In open: they lose bridging ions & open to differing degrees with helix-hinging motions.

Matthies D1, Dalmas O2, Borgnia MJ1, Dominik PK2, Merk A1, Rao P1, Reddy BG2, Islam S2, Bartesaghi A1, Perozo E3, Subramaniam S4. Cell. 2016 Feb 11;164(4):747-56. doi: 10.1016/j.cell.2015.12.055.

differential privacy

November 29, 2017


Box 1 of the following paper has a nice definition for differential privacy in genomics sense (phenotypic differential privacy): http://www.cell.com/cell-systems/fulltext/S2405-4712(16)30121-1 “