HTP discovery of novel developmental #phenotypes
http://www.nature.com/nature/journal/v537/n7621/full/nature19356.html New list of essential genes for the mouse, upping number to ~2900
Archive for the 'SciLit' Category
High-throughput discovery of novel developmental phenotypes : Nature : Nature Research
September 22, 2016Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer | Science
September 19, 2016high mutational burden predicts responsive patients
Inferring regulatory element landscapes and transcription factor networks from cancer methylomes | Genome Biology | Full Text
September 19, 2016The Path to Cancer — Three Strikes and You’re Out — NEJM
September 18, 2016Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. – PubMed – NCBI
September 18, 2016PETModule: a motif module based approach for enhancer target gene prediction : Scientific Reports
September 17, 2016PETModule…enhancer-target-gene prediction
http://www.nature.com/articles/srep30043 Compares activity
correlations against a Hi-C/ChIA-PET gold std.
Cancer undefeated. – PubMed – NCBI
September 11, 2016http://www.ncbi.nlm.nih.gov/pubmed/9164814
Bailar JC 3rd1, Gornik HL.NEJM
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Despite decades of basic and clinical research and trials of promising new therapies, cancer remains a major cause of morbidity and mortality. We assessed overall progress against cancer in the United States from 1970 through 1994 by analyzing changes in age-adjusted mortality rates."}}
Treatment of Acute Lymphoblastic Leukemia — 30 Years’ Experience at St. Jude Children’s Research Hospital — NEJM
September 11, 2016http://www.nejm.org/doi/full/10.1056/NEJM199310283291801#t=article
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When treated with effective multiagent chemotherapy, about two thirds of children with newly diagnosed acute lymphoblastic leukemia survive for long periods of time1-4. Much of this success can be credited to more intensive early treatment, especially of patients at higher risk of relapse.
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Result of Pinkel ’79 study
Synthetic microbe lives with fewer than 500 genes
September 10, 2016Synthetic microbe lives with fewer than 500 genes from @JCVenterInst http://www.ScienceMag.org/news/2016/03/synthetic-microbe-lives-less-500-genes 179 of the 479 genes have unknown functions
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“The microbe’s streamlined genetic structure excites evolutionary biologists and biotechnologists, who anticipate adding genes back to it one by one to study their effects. “It’s an important step to creating a living cell where the genome is fully defined,” says synthetic biologist Chris Voigt of the Massachusetts Institute of Technology in Cambridge. But Voigt and others note that this complete definition remains a ways off, because the function of 149 of Syn 3.0’s genes—roughly one-third—
remains unknown. Investigators’ first task is to probe the roles of those genes, which promise new insights into the basic biology of life.”
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